Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. However, the dose is usually not more than 10 mg of ezetimibe and 80 mg of atorvastatin. Drug information provided by: Merative, Micromedex. Children 10 years of age and older with heterozygous familial hypercholesterolemia (HeFH)At first, 10 mg once a day. An oral dose of atorvastatin will be absorbed rapidly, with maximum plasma concentrations occurring within 1 to 2 hours after you take it. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Take LIPITOR exactly as your doctor tells you to take it. What Are the Best PsA Treatments for You? Check with your prescriber to ensure that any other medications or supplements you may be taking will not interact with atorvastatin. 2017;11(4):972-985.e9. Of the total number of LIPITOR-treated patients in clinical trials, 15,813 (40%) were 65 years old and 2,800 (7%) were 75 years old. Dosage for children In the high-dose LIPITOR group, there were more patients with serious adverse reactions (1.8%) and discontinuations due to adverse reactions (9.9%) as compared to the low-dose group (1.4%; 8.1%, respectively) during a median follow-up of 4.9 years. Official answer by Drugs.com Atorvastatin (also known as Lipitor) can be taken any time of the day, with or without food. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 25 June 2023), ASHP (updated 11 June 2023) and others. Cognitive impairment was generally nonserious, and reversible upon statin discontinuation, with variable times to symptom onset (1 day to years) and symptom resolution (median of 3 weeks). Table 1 summarizes adverse reactions reported in 2% and at a rate greater than placebo in patients treated with LIPITOR (n=8755), from seventeen placebo-controlled trials. The skinny on fats. Could my Lipitor be causing memory loss. There are 5 disease interactions with atorvastatin which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The following are statins that must be taken at night: The author would like to recognize and thank Cody Ryan Thomas for contributing to this article. However, short-acting statins tend to work better at night because that is when your body produces most of its cholesterol, and short-acting statins clear from the body more quickly. These drugs may help stabilize the plaques on blood vessel walls and . effects of morning vs evening statin administration on lipid profile: a systematic review and meta-analysis, Antiviral drugs, such as tipranavir, ritonavir, lipinavir, and nelfinavir, Certain antifungals or antibiotics, such as itraconazole, ketoconazole, and clarithromycin, Desserts, such as doughnuts, cookies, cakes, and pies, Dairy products, such as butter, cheese, and milk. # See Section 7 for clinical significance. There was no significant difference between the treatment groups for all-cause mortality (Table 7). Acute liver failure or decompensated cirrhosis [see, Hypersensitivity to atorvastatin or any excipients in LIPITOR. Table 5: Effect of Co-administered Drugs on the Pharmacokinetics of Atorvastatin, Table 6: Effect of Atorvastatin on the Pharmacokinetics of Co-administered Drugs. In animal reproduction studies, no adverse developmental effects were observed in pregnant rats or rabbits orally administered atorvastatin at doses that resulted in up to 30 and 20 times, respectively, the human exposure at the maximum recommended human dose (MRHD) of 80 mg, based on body surface area (mg/m). Elevations of CK (>10 x ULN) were rare, but were higher in the LIPITOR group (0.1%) compared to placebo (0.0%). In rats administered atorvastatin during gestation and lactation, decreased postnatal growth and development delay were observed at doses 6 times the MRHD (see Data). If serious hepatic injury with clinical symptoms and/or hyperbilirubinemia or jaundice occurs, promptly discontinue LIPITOR. The number of LIPITOR-treated patients who required uptitration to 20 mg after Week 4 during the double-blind phase was 78 (56%). In addition to this medicine, your doctor may change your diet to one that is low in fat, sugar, and cholesterol. Statins are commonly used to lower bad cholesterol or low-density lipoprotein (LDL). Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. These findings occurred at plasma AUC (0-24) values of approximately 6 times the mean human plasma drug exposure after an 80 mg oral dose. The term "half-life" means the time it takes for half of the drug to be removed by the body. If you are taking certain medicines to lower cholesterol (eg, cholestyramine, colesevelam, colestipol, Questran, Welchol), take Liptruzet 2 hours before or 4 hours after taking these medicines. atorvastatin Uses, Side Effects, Dosage & Interactions - eMedicineHealth Temporarily discontinue LIPITOR in patients experiencing an acute or serious condition at high risk of developing renal failure secondary to rhabdomyolysis (e.g., sepsis; shock; severe hypovolemia; major surgery; trauma; severe metabolic, endocrine, or electrolyte disorders; or uncontrolled epilepsy). In this double-blind, placebo-controlled trial, patients were treated with anti-hypertensive therapy (goal BP <140/90 mm Hg for patients without diabetes; <130/80 mm Hg for patients with diabetes) and allocated to either LIPITOR 10 mg daily (n=5168) or placebo (n=5137), using a covariate adaptive method which took into account the distribution of nine baseline characteristics of patients already enrolled and minimized the imbalance of those characteristics across the groups. This medication is used along with a proper diet to help people lower "bad" cholesterol and fats (such as LDL(low-density lipoprotein), triglycerides) and raise "good" cholesterol (HDL) in the blood. Last updated on May 24, 2023. Mean plasma elimination half-life of LIPITOR in humans is approximately 14 hours, but the half-life of inhibitory activity for HMG-CoA reductase is 20 to 30 hours due to the contribution of active metabolites. Swallow the tablet whole. Erythromycin, clarithromycin, itraconazole, ketoconazole, posaconazole, and voriconazole. Inclusion in the trial required 1) a baseline LDL-C level 190 mg/dL or 2) a baseline LDL-C level 160 mg/dL and positive family history of FH or documented premature cardiovascular disease in a first or second-degree relative. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. There have been rare reports of immune-mediated necrotizing myopathy associated with statin use. However, since atorvastatin's half-life is 14 hours, when you take it should not matter greatly. Zeng R, Wang M, Zhang L. Is time an important problem in management of hypertension and hypercholesterolemia by using an amlodipine-atorvastatin single pill combination? Advise patients that LIPITOR may cause myopathy and rhabdomyolysis. If you take too much LIPITOR or overdose, call your doctor or Poison Control Center at 1-800-222-1222 or go to the nearest emergency room right away. Lipitor (atorvastatin) is a statin used for the treatment of elevated total cholesterol, LDL, triglycerides, and to elevate HDL cholesterol. The important property to look at in terms of appropriate dosing time is "half-life". Lipitor is a medication that contains atorvastatin. The dose of this medicine will be different for different patients. Plasma LIPITOR concentrations are lower (approximately 30% for Cmax and AUC) following evening drug administration compared with morning. Your doctor may increase your dose as needed. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. Monitor all patients for signs and symptoms of myopathy particularly during initiation of therapy and during upward dose titration of either drug. Consider liver enzyme testing before LIPITOR initiation and when clinically indicated thereafter. The incidence of these abnormalities was 0.2%, 0.2%, 0.6%, and 2.3% for 10, 20, 40, and 80 mg, respectively. The important thing with these statins is to pick a time that is best for you and to be consistent with taking it at around the same time each day. Insomnia and worsened sleep quality are potential side effects of using statins. Avoid combinations; the risk of the interaction outweighs the benefit. LIPITOR is extensively metabolized to ortho-and parahydroxylated derivatives and various beta-oxidation products. How High Cholesterol Levels Increase Stroke Risk, This New Drug Lowers Cholesterol Without the Side Effects of Statins. The following important adverse reactions are described below and elsewhere in the labeling: Because clinical trials are conducted under widely varying conditions, the adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Check with your doctor if you have health questions, concerns, or problems with this medication. Patients should closely follow the instructions included on the prescription label to ensure the effectiveness of the medicine. Atorvastatin (also known as Lipitor) can be taken any time of the day, with or without food. Encourage patients to optimize lifestyle measures, including regular exercise, maintaining a healthy body weight, and making healthy food choices [see WARNINGS AND PRECAUTIONS]. The following are statins that can be taken at night or in the morning: There may be other considerations to keep in mind while taking atorvastatin or other statins. Atorvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. LIPITOR dosage modifications are recommended for patients taking certain anti-viral, azole antifungals, or macrolide antibiotic medications [see DOSAGE AND ADMINISTRATION]. Concomitant use of cyclosporine, gemfibrozil, tipranavir plus ritonavir, or glecaprevir plus pibrentasvir with LIPITOR is not recommended. Atorvastatin is available under the following different brand names: Lipitor. Musculoskeletal and connective tissue disorders: rhabdomyolysis, myositis. In animal models, LIPITOR lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver and by increasing the number of hepatic LDL receptors on the cell surface to enhance uptake and catabolism of LDL; LIPITOR also reduces LDL production and the number of LDL particles. Last updated on Jan 19, 2022. When should atorvastatin 80 mg be taken? Alternatively, consider the ongoing therapeutic needs of the individual patient. Consider if the benefit of use of these products outweighs the increased risk of myopathy and rhabdomyolysis [see DRUG INTERACTIONS]. The safety and effectiveness of LIPITOR as an adjunct to diet to reduce LDL-C have been established pediatric patients 10 years of age and older with HeFH. Increases in HbA1c and fasting serum glucose levels have been reported with statins, including LIPITOR. Your dose depends on the reason why you're taking it, your cholesterol levels, and what other medicines you're taking. People 10 years and older: Initially, Lipitor should be given as 0 mg taken orally once daily; titrate at 4-week intervals; not to exceed 20 mg taken orally once daily; Homozygous Familial Hypercholesterolemia (Off-label) LIPITOR exposure may be increased by drug interactions due to inhibition of cytochrome P450 enzyme 3A4 (CYP3A4) and/or transporters (e.g., breast cancer resistant protein [BCRP], organic anion-transporting polypeptide [OATP1B1/OATP1B3] and P-glycoprotein [P-gp]), resulting in an increased risk of myopathy and rhabdomyolysis. (Pooled results are provided in Table 8. Lipitor Maintenance: 10-80 mg taken orally once daily; . Eighteen of 30 patients with persistent liver enzyme elevations continued treatment with a reduced dose of LIPITOR. You can take atorvastatin with or without food. The incidence of fatal hemorrhagic stroke was similar between groups (17 LIPITOR vs. 18 placebo). However, it has been shown that another drug in this class passes into human milk. Many drugs can interact, and some drugs should not be used together. This is because your body makes most cholesterol at night. There was no significant difference between the treatment groups for angina, revascularization procedures, and acute CHD death. In a study in pregnant rats administered 20, 100, or 225 mg/kg/day from gestation day 7 through to lactation day 20 (weaning), there was decreased survival at birth, postnatal day 4, weaning, and post-weaning in pups of mothers dosed with 225 mg/kg/day, a dose at which maternal toxicity was observed. You are encouraged to report negative side effects of prescription drugs to the FDA. General information about the safe and effective use of LIPITOR. Call 911 if your symptoms feel life-threatening or if you think youre having a medical emergency. & Represents ratio of treatments (co-administered drug plus atorvastatin vs. atorvastatin alone). Call your doctor immediately if you experience any unusual or troublesome symptoms including significant weight loss or gain, dark urine, fever, or fatigue. Some baseline characteristics, including hemorrhagic and lacunar stroke on study entry, were associated with a higher incidence of hemorrhagic stroke in the LIPITOR group [see ADVERSE REACTIONS]. Can I Drink Alcohol While Taking Lipitor and Other Statins? The reductions in LDL-C from baseline were generally consistent across age groups within the trial as well as with previous clinical trials in both adult and pediatric placebo-controlled trials. Following a single oral administration of 10 mg/kg of radioactive atorvastatin to lactating rats, the concentration of total radioactivity was determined. How long does atorvastatin stay in the system after stopping the drug? Cmax and AUC are each 4-fold greater in patients with Childs-Pugh A disease. Monitor all patients with renal impairment for development of myopathy.

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