Mycobacterial Lineages Causing Pulmonary and Extrapulmonary Tuberculosis, Ethiopia. Mycobacterium tuberculosis is the leading etiological agent of TB in humans, while M. bovis has a broader host range and is able to infect multiple host species, mainly cattle and including humans, with variable populational persistence . Genetic characterization of Mycobacterium tuberculosis in the West Bank, Palestinian Territories. Detection of Mycobacterium tuberculosis and Mycobacterium bovis from human sputum samples through multiplex PCR, Pakistan Journal of Pharmaceutical Sciences. No school contacts were retested, because their exposure had ended the previous May. With that in consideration the critical appraisal and quality assessment score, the selected sets of included studies were considered for quantitative analysis. An official website of the United States government. Not only in resource-limited countries, until the end of the 20th century, investigations of zoonotic TB in many of the developed countries were mainly based on phenotypic characteristics of the species such as colony morphology and use of biochemical tests (Sreevatsan et al., 1996). In 1940, pasteurization became obligatory, and in 1952, the percentage of M. bovis disease had dropped to 1.5%-2.0% in Amsterdam (1,2). CDC is not responsible for the content official website and that any information you provide is encrypted Findings of a meta-analysis generated from the full model showing the prevalence of Mycobacterium bovis (ES (95% CI)) stratified by genotyping- and conventional-based mycobacterial identification methods. Mycobacterium bovis is a slow-growing (16- to 20-hour generation time) aerobic bacterium and the causative agent of tuberculosis in cattle (known as bovine TB ). Persons with M. bovis infections should be asked about foodborne exposures. He recovered slowly and remained isolated at home until results from sputum smears were negative for AFB in August. Species distribution of the Mycobacterium tuberculosis complex in clinical isolates from 2007 to 2010 in Turkey: A prospective study. NVSL sequences the M. bovis isolates from all animal species; the size of the database is approximately 2,500 sequences. Infectious TB refers either to TB disease of the lungs or throat, which has the potential to cause transmission to other persons, or to the patient who has TB disease. http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5415a2.htm. The chapters are organized for quick access to well-indexed topics, and extensive reference lists are included to aid infectious disease specialists . Mycobacterium bovis, a member of theMycobacterium tuberculosis complex, is an important cause ofdisease in cattle, but it can also cause disease in humans [1]. Before collecting the relevant information, the full text of selected studies was further reviewed; and then six (31.57%) of the total 19 eligible studies were randomly selected and used for piloting the data collection tool. Khan SU, Rahman H, Ayaz S, Qasim M, Jabbar A, Khurshid M, Hussain M, Muhammad N, Rehman SU, & Ali N (2016). Genetic diversity of Mycobacterium tuberculosis Isolates from Assam, India: Dominance of Beijing family and discovery of two new clades related to CAS1_Delhi and EAI family based on spoligotyping and MIRU-VNTR typing. All studies that used primarily conventional-based identification methods reported significantly higher prevalence of zoonotic TB than studies that used primarily genotyping-based methods. Beside methodological differences on species isolation and identification, the proportion of human M. bovis cases reported by primary studies have shown significant variation that could also be due to some underlying conditions. In this review, this group is referred to as genotyping-based identification methods. M. tuberculosis is the main causative agent of human TB, and cattle are the primary host of Mycobacterium bovis; due to close interaction between cattle and humans, M. bovis poses a zoonotic risk. Siala M, Smaoui S, Taktak W, Hachicha S, Ghorbel A, Marouane C, Kammoun S, Gamara D, Slim L, Gdoura R, & Messadi-Akrout F (2017). Health and Human Services. Inclusion and selection criteria were defined based on the CoCoPop components of the review method. MMWR and Morbidity and Mortality Weekly Report are service marks of the U.S. Department of Health and Human Services. Tuberculin skin tests were used for U.S.-born contacts. Follow-up testing was not necessary for contacts at patient Bs school because the end of their exposure was >2 months before the investigation. Non-Hispanic U.S.-born individual exposed at patient As residence who reported no international travel at any time and no consumption of Mexico-origin unpasteurized dairy products. of pages found at these sites. Strain Diversity ofMycobacterium tuberculosislsolates from Pulmonary Tuberculosis Patients in Afar Pastoral Region of Ethiopia. In studies conducted by Nuru et al (Nuru et al., 2015) and Bayraktar et al (Bayraktar et al., 2011), all of the M. bovis cases were of EPTB origin. To shift the existing paradigm, there is a need to have updated and credible scientific evidence. Event rate (proportion of M. bovis) was estimated based on random distribution assumption of zoonotic TB prevalence. Bethesda, MD 20894, Web Policies Torres-Gonzalez P, Cervera-Hernandez ME, Martinez-Gamboa A, Garcia-Garcia L, Cruz-Hervert LP, Bobadilla-del Valle M, Ponce-de Leon A, Sifuentes-Osornio J (2016). Mller B, Drr S, Alonso S, Hattendorf J, Laisse CJM, Parsons SDC, van Helden PD, Zinsstag J (2013). Author summary Mycobacterium tuberculosis complex causes tuberculosis, a widespread burden for humans, and other mammals. From all 19 studies included in this review, a total of 7,185 MTBC species were isolated of which 702 (9.77%) were identified as M. bovis. Due to lack of a standard assessment tool that is developed for molecular prevalence studies, the quality of included studies was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist used for observational studies reporting prevalence data (Porritt et al., 2014). Bryan F. Buss, DVM1,2; Alison Keyser-Metobo, MPH2; Julie Rother3; Laura Holtz4; Kristin Gall, MSN2; John Jereb, MD5; Caitlin N. Murphy, PhD6; Peter C. Iwen, PhD6,7; Suelee Robbe-Austerman, DVM8; Melissa A. Holcomb, DVM2; Pat Infield2 (View author affiliations). Hence, all of those studies were excluded at this level and they were not considered in the remaining quantitative meta-analysis estimates. Although zoonotic TB is still reported from most continents in the world, it remains challenging to understand the real impact of the disease because of differences in identification methods. Additional supporting information may be found online in the Supporting Information section. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Evaluation of Genotype MTBC Assay for Differentiation of Clinical Mycobacterium tuberculosis Complex Isolates. Tuberculosis (TB) is among the most devastating human infectious diseases worldwide. 2020 Nov 30;14(11):e0008894. Yeboah-Manu D, Asare P, Asante-Poku A, Otchere ID, Osei-Wusu S, Danso E, Forson A, Koram KA, & Gagneux S (2016). Wedlich N, Figl J, Liebler-Tenorio EM, Khler H, von Pckler K, Rissmann M, Petow S, Barth SA, Reinhold P, Ulrich R, Grode L, Kaufmann SHE, Menge C. Front Vet Sci. SB was also funded by Defra, United Kingdom, ref: TBSE3294. We also observed a high variation in reported prevalence among studies conducted in the same country where the methodology differed. Like that of screening and data extraction procedures, quality of individual study and the overall risk of bias was assessed by two independent reviews (HT and SB). Similarly, as it is stated by Bayraktar et al. et al., 2016) from Mexico reported similar findings with a prevalence range of 26%30%. sharing sensitive information, make sure youre on a federal Although diagnosis and treatment of every person with TB is one of the key activities of the End TB Strategy, it has recently been recognized that people at risk of zoonotic TB have been neglected. Ramos Daniela Fernandes, Tavares Lucas, da Silva Pedro Eduardo Almeida, Dellagostin Odir Antnio (2014). In June 2014, patient B, a Hispanic girl aged 16 years, who was born in Nebraska to Mexican parents, sought medical care after 23 months of cough. Limited disease management and uncontrolled movement of infected cattle are factors contributing to the ongoing transmission of Mycobacterium bovis and that probably increases risk of zoonotic TB (Ameni et al., 2013; Torres-Gonzalez et al., 2013). Four months later, a U.S.-born Hispanic girl from a nearby town who had been ill for 45 months was also determined to have pulmonary TB caused by M. bovis. Therefore, this review and meta-analysis study aimed to summarize recent evidence and used to estimate the global prevalence of human M. bovis cases reported from epidemiological studies published in the last ten years. You will be subject to the destination website's privacy policy when you follow the link. Although the tool does not take into account the main features of molecular studies where the methodological quality is primarily maintained through standard laboratory procedures such as culturing and characterization of species, compared to other alternative quality assessment tools, it was found to be appropriate and sufficient enough to evaluate the overall quality of included studies. Field evaluation of the tuberculin skin test for the detection of Mycobacterium tuberculosis complex infection in communal goats (Capra hircus) in KwaZulu-Natal, South Africa. This person had no affiliation with the church or the school and reported no contact with patient B, who resided in a different town. All three were patient Bs family members who were also potentially exposed to patient A at the church. She recovered quickly and remained in isolation at home until late September. ZoonoticMycobacterium bovis-induced Tuberculosis in Humans. Therefore, all cross-sectional studies conducted globally through either a prospective or retrospective data collection method that reported the relevant disease condition were eligible to meet the context of the review. Portillo-Gmez L, Sosa-lglesias EG (2011). The result from nucleic acid amplification testing of sputum was positive for M. tuberculosis complex. Christianson S, Wolfe J, Orr P, Karlowsky J, Levett PN, Horsman GB, Thibert L, Tang P, Sharma MK (2010). The whole-genome sequencing results for all veterinary M. bovis isolates from Nebraska are distinct from those of both patients isolates. Hlavsa MC, Moonan PK, Cowan LS, et al. Furthermore, the revised protocol developed for review of diagnostic studies had also been considered to evaluate the reliability and validity of molecular identification techniques (Mclnnes et al., 2018). (2011), which was the highest M. bovis prevalence identified among included studies that were using genotyping methods (Jenkins et al., 2011). However, over the last three decades, many nucleic acid-based methods have been developed to differentiate strains within the Mycobacterium tuberculosis complex (MTBC), such as restriction fragment length polymorphism (RFLP) analysis, DNA sequencing of target genes and polymorphic DNA analysis (Cousins et al., 1991; Lee et al., 2000; Ramos et al., 2014; Watterson et al., 1998), as well as several PCR-based methods, such as spoligotyping and mycobacterial interspersed repetitive unit-variable number tandem repeats (MIRU-VNTR), which have been extensively used in parallel with commercially available test systems (Bidovec-Stojkovic et al., 2011; Christianson et al., 2010; Mathuria et al., 2008; Shi et al., 2018). Tuberculosis (TB) caused by Mycobacterium tuberculosis is a leading cause of human deaths due to any infectious disease worldwide. Particularly, studies that did not target identification of M. bovis from human samples or population-based comparative studies that estimated prevalence of zoonotic TB based on intradermal tuberculin skin test (TST) were excluded. The isolate was resistant both to pyrazinamide (PZA), which suggested that the infection was caused by M. bovis, and to low-concentration isoniazid (INH) (5). While subtotal estimates of seven studies conducted in Africa showed a lower contribution of M. bovis with an ES of 0.006 (0.0030.008). Isolates taken from the same patient were considered as separate episodes if six months apart from each other.
