P62 is brown staining (black arrow). professional. We'll respond you soon! Activation of necroptosis in multiple sclerosis. Directory of Qigong Teachers and Therapists - Qigong Institute Compared with the EA group, RIPK1, RIPK3, and MLKL protein expression in the EA + CQ group increased significantly at each time points after injection of inhibitor CQ (RIPK1: P < 0.01, P < 0.05; RIPK3: P < 0.05, P < 0.01; MLKL: P < 0.01, Figure 9). A., Griessenauer, C. J., Adeeb, N., Theodore, N., et al. After SCI, the rats were paralyzed in the hind limbs, without any movement phenomenon, with reduced diet and water, accompanied by urinary retention, and entered the stage of spinal cord shock, with a score of 0 point. After anesthesia with 10% chloral hydrate (3.0 mL/kg body weight) via intraperitoneal injection, a 5 cm longitudinal incision was made dorsally on the rats. Ji is a Master of Science in Oriental Medicine and he is certified as a licensed acupuncturist by both the Acupuncture Board of California. Rats in Sham, Model, and EA groups (n = 6) at 3 and 7 days time points were euthanized. Operation method: The upper and lower spinous process gaps (proximal end at the top, distal end at the bottom) in the damaged area were selected to open points within 7 mm. 14:616864. doi: 10.3389/fnins.2020.616864. Intrathecal injection of 3-methyladenine reduces neuronal damage and promotes functional recovery via autophagy attenuation after spinal cord ischemia/reperfusion injury in rats. 18:1865. doi: 10.3390/ijms18091865, Zhang, D., Xuan, J., Zheng, B. 43, 425441. The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author/s. Figure 9. Dr. Ji has already been practicing acupuncture in Denver area for over a decade. I had tried every preventative measure that was available in main stream medicine, including relaxation therapy with a psychologist. B., Zhou, Y. L., Lin, Y., Wu, Y. S., et al. doi: 10.1016/j.neuroscience.2014.02.007, Wang, Y., Wang, J., Wang, H., Feng, X., Tao, Y., Yang, J., et al. However, the hematoma was the most severe in 3 day, indicating that the vascular hemorrhage of the spinal cord after external impact caused congestive necrosis, leading to further aggravation of tissue ischemia. Spine J. 5300 Dtc Pkwy Ste 330 Greenwood Village, CO 80111. The data were presented as mean standard deviation ( SD). All authors contributed to the article and approved the submitted version. The rats were placed in the open field and moved freely for 5 min. Acupuncture alternative Medicine Clinic in Houston, TX - Houston Acupuncturists are alternative medical professionals who use needles to stimulate certain parts of the body. Mean optical density of MLKL in each group (IOD/Area). Dong Ji, Acupuncturist in San Diego | Patient Reviews | HealthSoul The name represents the Earthly Mother (Kun ) extending her power to Heal and Assist (Ji ) those in need. 24, 905918. To request an appointment, choose to call the office directly or fill out the request form below. Autophagosomes accumulated significantly. You may be a miracle worker! Today, I am 73 years old and visit QiaoLi as often as I can. Most times, I actually fell asleep! Acupuncture Physician Jiji Cook is a specialist in treatments for Fertility & Pregnancy, Pediatrics and treatments for Pain Relief and Pain Management. The average optical density value of LC3 in the EA group was higher than that of the Model group at all-time points (P < 0.05), while the average optical density value of P62 was lower than that of the Model group (P < 0.05), indicating that EA treatment promoted the increase of LC3, reduced the expression of P62, and accelerated autophagy flux. Rodent models have become standard in the past 30 years and have been widely used in SCI research (Kwon et al., 2015). Data are expressed as the mean SD (n = 6 rats/group). In model group, neuron disappear compared to Sham. At the time point 7 days after SCI, the loss of gray matter neurons in the Model group was still significant, the necrotic cavity gradually expanded, which showed the ghost cell of dead neurons, the decrease of inflammatory cells compared with that at 3 day, and a large number of glial cells proliferated. Autophagy flux is a dynamic process involving the formation, transmission, and degradation of autophagosomes. (B) HE stained images of spinal cord sections (200). The beneficial or harmful functions of autophagy may depend on the induction or inhibition of autophagy flux after central nervous system injury. My whole family has benefited from the talent and experience at Shie Ji. Call us today to schedule an appointment. of America could benefit by looking into TCM! No side effects or "experimenting with drugs" as had been previously recommended by a confounded Dr. Western medicine is great for emergencies but we've found Traditional Chinese Medicine to be better at diagnosis and health maintenance. The average OD value of RIPK1, RIPK3, and MLKL in the Model group was significantly higher than that of the Sham group at 3 and 7 days after injury (P < 0.01). The SCI model was then produced using a NYU Impactor M-III strike (a 10 g pouching rod of 2.5 mm diameter with drop of 50 mm and damage of 50 gcm) at the T10 segment to create relatively serious injury (Verma et al., 2019). These results indicated that EA treatment could inhibit the formation of necroptosis factor RIPK1, RIPK3, MLKL, reduce the formation of necrotic complex, and protect the remaining neurons. Our appointments link here. (2015). Cell Rep. 10, 18361849. Great family, great place! To further explore the effect of autophagy flux on rat hind limb function, lysosome inhibitor chloroquine CQ was applied. QiaoLi Lei continues to impress me with her outstanding skills. Rats were randomly divided into four groups: Sham group, SCI group, EA group, and EA + CQ group. *Correspondence: Guan Fulin, fulinguancn@outlook.com; Sun Zhongren, szr006@163.com, These authors have contributed equally to this work and share first authorship, Translational Advances in Alzheimer's, Parkinson's, and other Neurodegenerative Dementias, View all This result also indicates that EA could increase autophagy flux and promote autophagy degradation, consistent with the results that increase of LC3 expression and decrease of P62 expression mentioned before. Here at Ji Acupuncture & Oriental Medicine, we help with things like arthritis, back pain, Bursitis, neck pain, tennis elbow, carpal tunnel, benign tumors, diabetes and more. Western blot results of the expression of LC3-II and P62 protein. Praise God for this wonderful clinic. (2016). It is meant to relieve pain, promote healing, and improve physical, mental, and emotional health and well-being. Rev. I remember my grandmother always served freshly cooked rice to family and guests. I also used acupuncture to help induce labor and delivered within 5 hours of receiving the treatmenta VBAC nonetheless! Spinal cord injury (SCI) 2016 facts and figures at a glance. The continued increase of LC3-II protein expression after acupuncture treatment may be related to the promotion of autophagy. RIPK1 is recruited by P62 [the ZZ domain of P62 can interact with RIPK1 (Puissant et al., 2012)] to the autophagosome, which activates the assembly of necrosome and further mediates cell death. Sci. 42C for 15 min and 85C for 5 s for reverse transcription. Got a question about Ji Acupuncture & Oriental Medicine? LC3-II is generally considered as an autophagosome marker, because the content of LC3-II reflects the number of autophagosomes. The receptor-interacting protein kinases 1 (RIPK1) and the sequential activation of downstream RIPK3 and the mixed lineage pseudo-kinase MLKL regulates necroptosis which leads to neuronal and glial cell death after SCI (Liu et al., 2015a; Weinlich et al., 2017). This is a common aspect of Chinese medicine, and is most commonly used to relieve pain through acupuncturist Denver. Acupuncturists stimulate certain points in the body that trigger the nervous system to release chemicals that produce a desired effect. Copyright Acupuncture & Oriental Medicine | 5300 DTC Pkwy Suite 330, Greenwood Village, CO 80111, Denver Acupuncture - Specialists In Chinese Medicine. And 3 and 7 days subgroups were focus of subsequent studies. CQ could improve the pH-value of lysosomes and then destroy the function of lysosomes, inhibit fusion of lysosomes and autophagosomes, thus leading to the accumulation of autophagosomes and blockage of the autophagy flux. Effects of EA on the expression of necroptosis markers. (G): ##P < 0.01, vs. Sham group; *P < 0.05, vs. Model group. doi: 10.1179/2045772314y.0000000224, Liu, S., Li, Y., Choi, H. M. C., Sarkar, C., Koh, E. Y., Wu, J., et al. Biol. Resveratrol improves neuron protection and functional recovery through enhancement of autophagy after spinal cord injury in mice. The Best Acupuncturist in Central Arkansas. Testimonials | Yan JI Acupuncture | Discomfort And Pain Relief We offer acupuncture services to treat several disorders. Traumatic spinal injury: global epidemiology and worldwide volume. It has been proven to increase success rates of IVF (in vitro fertilization) by nearly twenty percent when administered in a German study in 2002. Jewish Home of San Francisco Fluent in English, Mandarin, and Cantonese, some Japanese and Spanish. After the injection of inhibitor CQ, the average optical density values of LC3, P62, RIPK1, RIPK3, and MLKL in the EA + CQ group increased at each time point, which was statistically significant compared with the EA group at each time point (P < 0.05). While electro-acupuncture could promote the expression of LC3 and increase the formation of autophagosome. The current location address for Ji Acupuncture & Herbs is 2035 Westwood Blvd Ste 209, , Los Angeles, California and the contact number is 626-422-7323 and fax number is . Doctors who also practice acupuncture are called medical acupuncturists. Thank you so much Dr. Lei! Ji Acupuncture & Oriental Medicine is open Mon, Tue, Wed, Thu, Fri. doi: 10.18632/oncotarget.10640, Grossman, R. G., Fehlings, M. G., Frankowski, R. F., Burau, K. D., Chow, D. S., Tator, C., et al. Certified Acupuncturist in Parker Colorado | Chinese Medicine Clinic Transverse paraffin sections (5 m thick) were placed on slides. Repeat extend the gap and remove the vertebral plate and T10 spinous process, and expose the intact spinal cord. Endorphins also play an important role in the functioning of the hormonal systems, they regulate serotonin in the brain which plays a role in human disposition. Needle treatment is a procedure that involves implanting incredibly small needles into your skin at specific places on your body, which we treat using acupuncture. 2473 Merrick Road Bellmore, NY 11710 Call Yan Yan Yu (646) 647-3127 Nearby Areas Additional Location Whitestone Physical Therapy of Queens, P.C. However, a copy will be sent to you for your records. With Acupuncture and Chiropractic care, we can help guide your body onto the right path in a holistic way with a personalized treatment plan. A. The degradation of autophagy substrate P62/SQSTM1 is another marker widely used to evaluate autophagy activity, which can recruit ubiquitin substrates into autophagosome and degrade with it (Yoshii and Mizushima, 2017). The hemorrhagic lesion was reduced compared with that of 3 day, while the above pathological symptoms were improved after treatment in the EA group. The association of palmitoylethanolamide with luteolin decreases autophagy in spinal cord injury. CQ destroyed lysosome function by inhibiting the fusion of lysosome and autophagosomes, leading to the accumulation of autophagosomes, and blockage of autophagy flux. Electro-acupuncture group (EA) performed Jia-Ji electro-acupuncture therapy 6 h after SCI. List of acupuncture points. (2017). However, its work mechanism is still unclear. Home | Jin's Acupuncture Clinic - Bellevue Animals models of spinal cord contusion injury. Please see our Forums for more information. Acupuncturists may also be trained in other areas of medicine. doi: 10.1016/j.expneurol.2015.04.008, Kwon, B. K., Tetzlaff, W., Grauer, J. N., Beiner, J., and Vaccaro, A. R. (2004). Primary antibodies: RIPK1 (1:100, RIPK1 Rabbit PolyClonal antibody, United States Proteintech), RIPK3 (1:40, Rabbit PolyClonal antibody, Beijing BIOSS), MLKL (1:200, Rabbit PolyClonal antibody, United States Affinity), LC3B (1:500, Rabbit polyclonal antibody, United States Proteintech), P62 (1:200, Rabbit polyclonal antibody, United States Proteintech). doi: 10.1016/s1474-4422(18)30415-0, Goodall, M. L., Cramer, S. D., and Thorburn, A. Tai Ji Acupuncture, P.C., Acupuncturist, Bellmore, NY, 11710 Science 353, 603608. Second antibody: anti-rabbit (PV-6,001, Beijing Zhongshanjinqiao). Dong Ji has not indicated on the profile that their office offers tele-health visits. That is why the acupuncture therapy is becoming more and more popular for weight reduction right now. For the past 10 years I experienced at least one migraine per week. Finally, sections were incubated with DAB, hematoxylin redyeing, and mounted on coverslips. doi: 10.1038/nrm.2016.149, Xiong, F., Fu, C., Zhang, Q., Peng, L., Liang, Z., Chen, L., et al. Our commitment to staying updated in the profession enables us to provide the best comprehensive treatment possible. Sze K. Chan, L.Ac. KUN JI ACUPUNCTURE LG and LX contributed important reagents and provided technical assistance. The membrane were washed 3 times with Tris-buffered saline Tween, and incubated with secondary antibody at 37C for 1 h as shown below: HRP-Goat-Anti-Rabbit IgG(H + L) (1:5,000, United States Proteintech), HRP-Goat-Anti-Mouse IgG(H + L) (1:5,000, United States Proteintech). Indications: Pain in the costal and cardiac regions, scrofula, cold pain of the elbow and arm, dryness of the throat. It is meant to relieve pain, promote healing, and improve physical, mental, and emotional health and well-being. Pain 32, 1221. Houston Taiji KungFu Health Academy | Home Neuroscience 266, 91101. Dr. Ji offers traditional Chinese acupuncture, Chinese herbs, electroacupuncture, cupping therapy, Tui Na (acupressure), Gua Sha; specializes in pain management, infertility, anxiety, insomnia, allergy, Bells palsy, ED, BPH, diabetes, weight loss, women health, wellness, etc. (F): ##P < 0.01, vs. Sham group; *P < 0.05, **P < 0.01, vs. Model group. Its working. The rash disappeared in a matter of days! While after EA treatment, several neurons could be seen, the damage tissue and inflammation factors reduce. (2018). Function: Frees the channels and quickens the connecting vessel, regulates Qi and blood. many ways. Theyre a great team and you can feel that they truely care. The counsellor should respond to you by email, although we recommend that you follow up with a phone call. I went here awhile back got heart issues and she helped .. Basso-Beattie-Bresnahan assessment showed improvement of hind limb motor function after Jia-Ji electro-acupuncture treatment. I consider QiaoLi Lei a gift from God, and I feel blessed to know her and have her help. In this figure, the image of neuronophagia and nodular microglia could be seen. The mean optical density values of spinal cord tissues RIPK1, RIPK3, and MLKL in the Model group were significantly higher than those in the Sham group at 3 and 7 days after surgery (P < 0.01). Certified Acupuncturist in Highlands Ranch Colorado | Chinese Medicine ##P < 0.01, vs. Sham group; &P > 0.05, **P < 0.01, vs. Model group. ##P < 0.01, vs. Sham; *P 0.05, vs. Model; &&P < 0.01, &P < 0.05, vs. EA. The number of lysosomes, especially secondary lysosomes/active lysosomes, autophagosomes, and autolysosomes in the EA group was greater than that in the model group (Figure 4D). At the time points of 3 and 7 days after surgery, the number of neurons in the Model group was significantly reduced, while neurons relatively increased after treatment in the EA group, statistically significant compared with the Model group at each time point (P < 0.05, P < 0.01). The needles may be manipulated manually or stimulated with small electrical currents (electroacupuncture). No axonal denaturation and granular disintegration were observed, no autolysosome was found, and several primary lysosomes could be seen (Figure 4A). RIPK1, RIPK3, and MLKL were brown-yellow positive, mainly expressed in neuron and glial cells (red arrow). Ji Acupuncture | Denver Acupuncture | Best Chinese Acupuncture | Pain Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Molecular mechanisms of necroptosis: an ordered cellular explosion. Patient Forms. Some adjunctive therapies are used as an effective treatment of acute SCI clinically, such as corticosteroids (Schroeder et al., 2014), neuroprotectant agents (Grossman et al., 2014), and alternative therapy (electro-acupuncture) (Xiong et al., 2019). When autophagy meets cancer through p62/SQSTM1. 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Remember to double check your return email address or your phone number if you prefer to be called. 9, 46074616. Electro-acupuncture + inhibitor chloroquine group (EA + CQ) received both EA and inhibitor CQ treatment after SCI. My body always feels so much more healthy and whole after a session. EA could improve the pathological changes. These pathology changes are associated with cells and necrotic neurons apoptosis, known as vacuolization of neurons. The gray matter structure was relatively complete, the nerve fibers were arranged in a more orderly manner, the boundary between gray matter and white matter could be observed, the number of neurons was more, the number of cavities was less, and the inflammatory cell infiltration was improved (Figure 2B). Send this email to request a video session with this counsellor. The rats in each group were dynamically evaluated according to the 6 h, 1, 3, and 7 days after SCI. At 3 and 7 days time points, there were statistically significant reducing in the number of anterior angular motor neurons in Model group compared to Sham group (P < 0.01). J. Neurotrauma 12, 121. Both Dr. Lei and Dr. Yi both provided my acupuncture treatment and Dr. Lei has also treated me with herbal medicines. Rats in the SCI, EA and EA + CQ groups were further divided into four subgroups by various time points of treatment: 6 h, 1, 3, and 7 days. trained in China. Loading sample for electrophoresis and then transferred the protein to the PVDF membrane. ##P < 0.01, vs. Sham; *P < 0.05, vs. Model; &&P < 0.01, vs. EA. Specific inhibition of RIPK1 kinase activity is found to block necroptosis and inflammation (Degterev et al., 2008). See how easy and satisfying acupuncture can be with Dr. Yan Ji at Ji Acupuncture of Denver CO. We are one of the top rated Denver acupuncturists for a reason. We are most fortunate to have such a gifted healer in our community. Call 999 or your nearest hospital. On 3 day after SCI, the cytoplasm of neurons in the spinal cord tissue had sustained extensive edema, the mitochondria were swollen significantly, the myelin lamina was broken, the rough endoplasmic reticulum was loose, the number of lysosomes increased (Figure 4B). To find out more about acupuncture and fertility, see here. LC3 is brown staining (black arrow). Her son Dr Xuan Yi 6th generation. The Nissl body is a marker of the functional state of neurons. Electron microscopy results of the spinal cord tissue sections after EA. Acupuncture on treating asthma - PMC - National Center for (C) Immunohistochemical staining results of P62 in each group (400 ). doi: 10.1038/cddis.2014.527, Mortazavi, M. M., Verma, K., Harmon, O. Electroacupuncture at Jing-jiaji points for neck pain caused by Of course, Chinese doctors have known of the benefits of TCM in the treatment of infertility long before it was ever studied in the West, with the first known publications on infertility appearing several hundred years ago. J. Spinal Cord Med. In rat model of SCI, we observed that there was a significant improvement on motor function after EA treatment compared to Model group at 3 and 7 days time points (P < 0.01). Spine (Phila Pa 1976) 39, 971977. After routine disinfection, inserted the needle into the spine with a needle tip to the lamina (depth is 13 mm). She also learned more from her grandfather . Jessica is a Senior Teacher Trainer for the Institute of Integral Qigong and Tai Chi. These include certifications in Clean Needle Technique, Acupuncture and Chinese Herbology. 303-337-2866. Tai Ji Acupuncture, P.C. In the treatment of infertility, it has also been shown to increase blood flow to the uterus. Data are expressed as the mean SD (n = 6 rats/group). Inhibition of lysosomal/autophagy pathways and activation of necroptosis have been shown to lead to cell loss and tissue damage in some CNS trauma models (Sarkar et al., 2014; Lipinski et al., 2015). Female Sprague Dawley rats (220250 g body weight), aged 10 weeks old, were obtained from the central animal of Heilongjiang Chinese Medicine university. What do we treat? For further comparison between groups, the least significant difference (LSD) test was used for those with homogeneous variance, and Dunnetts T3 test was used for those with heterogeneous variance. and other problems. doi: 10.1007/s10143-018-1008-3, Sarkar, C., Zhao, Z., Aungst, S., Sabirzhanov, B., Faden, A. I., and Lipinski, M. M. (2014). 96 were here. doi: 10.1016/j.neures.2011.03.010, Ito, Y., Ofengeim, D., Najafov, A., Das, S., Saberi, S., Li, Y., et al. Cell Death Dis. Average optical density values of LC3 and P62 were significantly higher than that of Sham group at 3 and 7 days postoperatively (P < 0.01). Acupuncture: What You Need To Know | NCCIH However, a copy will be sent to you for your records. A sensitive and reliable locomotor rating scale for open field testing in rats. But, it helps and did so immediately. Of course, Chinese doctors have known of the benefits of TCM in the treatment of infertility long before it was ever studied in the West, with the first known publications on infertility appearing several hundred years ago. Dr. Yan Ji is a fully licensed and board-certified acupuncturist. A patient with "Xiao Ke" or wasting and thirsting disease (the Traditional Chinese medical term for diabetes) is discussed in detail in the Nei Jing, a classic Chinese medical book written about 2,500 years ago. Dong Ji accepts various types of health insurance, but individual coverage may be variable. (H): ##P < 0.01, vs. Sham group; *P < 0.05, vs. Model group. Testimonials. doi: 10.1002/ca.22432, National Spinal Cord Injury Statistical Center (2016). Rapid diagnosis and neuroprotective interventions at the stage of acute injury are therefore critical, and these treatments have the potential to significantly improve subsequent long-term functional recovery. Data are expressed as the mean SD (n = 6 rats/group). The myelin sheath is arranged around the axon in concentric circles. If you are looking for acupuncture near me then Ji Acupuncture & Oriental Medicine is the best. She's very good and, informative about acupuncture and she will teach you what it's about. doi: 10.1016/s0079-6123(09)17508-8, Basso, D. M., Beattie, M. S., and Bresnahan, J. C. (1995). New patients are welcome. If you prefer corresponding via phone, leave your contact number. Thus, the interaction of lysosomal/autophagy and necroptosis may play a key role in improving neuronal survival and functional outcomes after SCI injury. These data make the case that Jia-Ji electro-acupuncture treatment may improve locomotor function by promoting autophagy flux and inhibiting necroptosis. Ensure adequate food and water, assist urination once in the morning and evening until the reflex of urination was restored, and massaged the abdomen of rats clockwise every day to prevent flatulence and difficulty in defecation. Shie Ji Acupuncture & Chiropractic is Awesome! The second part mainly evaluates the gait and hind limb coordination ability, with a score of 813. (2008). Besides, the expression peak of LC3 and P62 at 3 day was in accordance with that of necroptosis factors.

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